Cannabidiol (CBD) found to cut seizures in HALF among severe epilepsy patients, scientists find
Taking cannabis-based medicine may significantly reduce the number of seizures by half in children and adults with a severe form of epilepsy called Lennox-Gastaut syndrome (LGS), according to a recent study. Researchers said Lennox-Gastaut syndrome starts in childhood, and that patients with LGS experience multiple kinds of seizures: drop seizures and tonic-clonic seizures.
During a drop seizure, the patients’ muscle tone changes, which then causes them to collapse. On the other hand, tonic-clonic seizures involve loss of consciousness and full-body convulsions. According to researchers, these types of seizures are difficult to manage and usually do not respond well to drug treatments. In addition, patients with LGS usually suffer from impaired intellectual development. Furthermore, researchers noted that drop seizures often lead to injuries and emergency department visits.
To assess the efficacy of cannabidiol, researchers examined 225 patients with LGS who experience 85 drop seizures a month on average. The participants were then given either 20 mg/kg daily cannabidiol, 10 mg/kg daily cannabidiol, or placebo as an add-on therapy to current drug treatment. The study revealed that patients in the high-dosage group had a 42 percent reduction in drop seizure frequency at 14 weeks. Of these patients, 40 percent reported reducing their seizures by half or more.
The study also showed that patients in the low-dosage group attained a 37 percent overall decrease in drop seizure frequency. Of these patients, 36 percent reported reducing their seizures by half or more. In contrast, patients in the placebo group only had a 17 percent overall reduction in drop seizures. Researchers also found that only 15 percent of the controls reported reducing their seizures by half or more
“Our results suggest that cannabidiol may be effective for those with Lennox-Gastaut syndrome in treating drop seizures. This is important because this kind of epilepsy is incredibly difficult to treat. While there were more side effects for those taking cannabidiol, they were mostly well-tolerated. I believe that it may become an important new treatment option for these patients,” said study author Dr. Anup Patel in ScienceDaily.com.
The findings were slated for presentation at the American Academy of Neurology‘s 69th Annual Meeting in Boston, Massachusetts.